The Big Chill- Will therapeutic hypothermia make it to prime time?-Ben Brian-03/07/2006 - 8:30am

Event Information
Event Topic: 
The Big Chill- Will therapeutic hypothermia make it to prime time?
Event Date: 
03/07/2006 - 8:30am
Event Location: 
NOVA
Speaker Information
Event Speaker: 
Ben Brian
Event Speaker Title: 
Senior Vice President
Event Speaker Company: 
Radiant Medical, Inc.
Event Speaker Bio: 

After getting conventional degrees in chemical engineering, Mr. Brian discovered the medical device side in 1984 from Professor William Dorson, who was conducting research at that Harvard of the Southwest, Arizona State University. Although Ben's previous experience with extracorporeal blood flow had been limited to the Rugby pitch, he was able to complete his doctorate on a methodology to remove bilirubin from blood for the treatment of neonatal jaundice. Leaving academia for greener pastures in ‘89, Ben took a research position with COBE laboratories outside Denver. In between the discovery of skiing and kids, Ben worked at COBE on development projects for selective blood filters, membrane oxygenators and eventually led the implementation of COBE’s biomaterials platform. As the marketing group found coagulation cascade discussions with surgeons too intimidating, Ben made a move to “the dark side” to cover that role in marketing. In ‘98, he left the shadow of the Coors Brewery for the rolling hills of Central NJ, where besides having his sanity questioned, he took a job as a Strategic Marketing Director for the Ethicon division of J&J. There he was responsible for global strategic and market opportunity assessments for the Ethicon Franchise - basically where should the company invest in emerging technologies? Late in ‘99, he was conducting due diligence on Cardiovention, a bay area start-up looking to revolutionize cardiac surgery. Intrigued and excited about the potential, he left J&J for the very affordable confines of Silicon Valley. In his role as Vice President of R&D, he basically stayed out of the way of the development of a minimally invasive circulatory support system, which received several national design awards. Ready to emerge on the global scene, Cardiovention unexpectedly had to table plans and pursue litigation against a large Midwestern company, which will remain nameless. Late in ‘03, Radiant Medical was desperate enough to hire Ben for a major redesign of their catheter based temperature management system. As a cruel joke, he assumed responsibility for the Operations group as well in ‘05. With the new system complete, Radiant is back again on the rise with two pivotal IDE trials of therapeutic hypothermia. Ben has a couple patents here and there, an honorary doctorate from Rose-Hulman, and hopes to hit the 25 gallon blood donation milestone at the Stanford Blood Center this spring.

Event Details
Cost: 
$0 - Free
Event Details: 

An extensive, consistent, and persuasive body of data convincingly demonstrates that cooling protects endangered cells, prevents tissue death, and preserves organ function. Therapeutic cooling has been used clinically for a half-century in applications such as cardiovascular surgery, neurosurgery, organ transplantation, and more recently in fever control, and cardiac arrest. Therapeutic cooling is a multimodal solution. Mechanisms of protection include reduction of metabolism, preservation of ATP, stabilizing the mitochondrial membrane, inhibition of reactive oxygen species production, decreasing microvascular injury, inducing heat shock proteins, inhibition of stress kinases and protein kinases, inhibition of apoptosis, inhibition of inflammation, and inhibition of platelet aggregation. With all this benefit, why is there not a plethora of cooling treatment devices/options which have been proven effective across a wide range of clinical practice? The purpose of this presentation is to provide some engineering insight behind what technologies are out there today, what is on the horizon, and where might devices/drugs ultimately play a role in mainstream medical applications of hypothermia.